Tag Archives: osteoarthritis

50% improvement in pain-related questions by the end of the study (60 days)

NEM paper

A new study was conducted at six different clinical sites throughout Germany to evaluate the efficacy and tolerability of NEM® for the relief of the pain and discomfort associated with osteoarthritis of the knee and/or hip.

NEM® is a natural source of collagen, chondroitin, and hyaluronic acid, each of which is known to support joint health. Much of the benefit with NEM® is thought to be the result of its nutrients boosting the production of critical joint molecules.

Forty-four patients were treated with a daily dosage of 500 mg of NEM®. Clinic visits were scheduled for subjects at study initiation and at 60 days following the onset of treatment. Statistical analysis revealed that supplementation with NEM® produced a significant pain relieving effect within 10 days. On average, nearly 1/4th of the subjects experienced a 30% improvement in pain-related questions within 10 days and almost 20% of the study population experienced a 50% improvement in pain-related questions by the end of the study (60 days). Significant improvement for stiffness was noted at 30 and 60 days after treatment.

An indication of the pain relieving effect of NEM was a drop in analgesic use. For the 30 days prior to study commencement, patients consumed on average 7 doses of acetaminophen. Analgesic use had dropped considerably to 2.43 doses per 30 days after 30 days of supplementation with NEM®.

No side effects were noted with NEM®.

Product link: NEM® capsules

Study link: NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study. 2014

Naturopathic Physician, Dr Michael Murray comments on osteoarthritis: What is osteoarthritis?

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Safe & effective use of MSM in knee arthritis

In a just published study, the natural supplement methylsulfonylmethane (MSM) was shown to be effective in managing the pain and limited mobility associated with degenerative osteoarthritis arthritis (OA) in the knees. This painful problem is commonly managed with conventional anti-inflammatory drugs but form many the side effects of these agents outweigh the benefits. The authours of the current study commented on “the lack of clinical side effects” associated with the MSM therapy and that “current research suggests that if side effects to MSM exist, they are minimal and include minor GI symptoms, headaches, insomnia and difficulty concentrating“.

The sudy concluded that; “Patients with OA of the knee taking MSM for 12 weeks showed an improvement in pain and physical function. The results suggest that larger and long- term studies may find additional and greater improvements in knee OA symptoms. These improvements, however, are small and it is yet to be determined if they are of clinical significance. Further trials on MSM are recommended to define the safety, efficacy and appropriate dosage of MSM. We recommend incorporating longer intervention periods, larger and wider patient populations, dose-response trials and comparisons with other health supplements and standard conventional treatments.”

View the study here:

Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complementary and Alternative Medicine 2011, 11:50

MSM product link

Pure Opti-MSM 1000mg supplement

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Arthritis & Artery Disease

Hand osteoarthritis in older women appears to be associated with carotid and coronary atherosclerosis, Icelandic and US researchers report in the November issue of Annals of the Rheumatic Diseases.

“These results” lead investigator Dr. Helgi Jonsson told Reuters Health, “indicate a linear association between the severity of hand osteoarthritis and atherosclerosis, suggesting that the pathological processes have certain components in common.”

Dr. Jonsson of Landspitalinn University Hospital, Reykjavik and colleagues examined data from a population-based study of Icelanders involving 2264 men and 3078 women with a mean age of 76 years.

After adjustment for age and other confounders, in women, both carotid plaque severity and coronary artery calcification were significantly associated with hand osteoarthritis. For coronary artery calcification, the odds ratio was 1.42 and for moderate or severe coronary plaques, it was 1.25.

Both of these factors showed significant linear trends in relation to hand osteoarthritis in women over the whole cohort. However, no significant relationships were seen in men.

“Our results,” say the investigators, “lend support to theories indicating that vascular pathology is an integral part of the osteoarthritis process.”

Dr. Jonsson concluded “I consider this a major step forward in our understanding of the systemic nature of osteoarthritis and think that further studies of hand osteoarthritis may provide the key necessary for the understanding and treatment of osteoarthritis.”

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