Tag Archives: breast cancer

Fish Oils Lower Breast Cancer Risk

A new paper just published in the British Medical Journal concludes that “Higher consumption of dietary marine n-3 PUFA is
associated with a lower risk of breast cancer.” With the ease of availability of fresh oily fish and the abundance of high quality fish oil supplements may be its time to re-think your fish oil intake…

Read the study for yourself here: http://www.bmj.com/highwire/filestream/651721/field_highwire_article_pdf/0/bmj.f3706


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Resveratrol Blocks The Growth Effects Of Oestrogen By Reducing The Specific Breast Cancer Receptors

A new research report appearing in the October 2011 issue of The FASEB Journal shows that resveratrol, the “healthy” ingredient in red wine, stops breast cancer cells from growing by blocking the growth effects of oestrogen. This discovery, made by a team of American and Italian scientists, suggests for the first time that resveratrol is able to counteract the malignant progression since it inhibits the proliferation of hormone resistant breast cancer cells. This has important implications for the treatment of women with breast cancer whose tumors eventually develop resistance to hormonal therapy. 

Read the story in Medical News Today: Resveratrol Blocks The Growth Effects Of Estrogen By Reducing The Specific Breast Cancer Receptors.

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Vitamin D & breast cancer: new findings

We are posting a growing number of articles and reports relating to vitamin D and health. Ongoing research is revealing so many key biochemical roles for this nutrient we feel duty bound to report them as they are published. For some time clinicians have noted that vitamin D may reduce breast cancer risk. The latest study in this area now suggests that this occurs through an effect on steroid hormones in normally cycling (menstrual cycle) women. The study was conducted to determine whether there was an association between circulating vitamin D and estradiol and progesterone in young women. Volunteer women aged 18-22 (not using hormonal contraceptives) were recruited during summer and winter. They provided lifestyle information and a blood sample. The women recruited in winter gave a second sample after taking vitamin D supplement for 4 weeks. There were 101 women sampled during the luteal phase (1-14 days prior to the start of the next menstrual period).

The results of this study indicated that as vitamin D levels increased there was an associated decrease in progesterone and estradiol after adjustment for age, body mass index, ethnicity, season, alcohol use, smoking, and physical activity. The study concluded that higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women.

Journal abstract:

Vitamin D association with estradiol and progesterone in young womenCancer Causes Control. 2010 Mar;21(3):479-83.

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Mammograms: there is no right answer…

Researchers are again questioning what was once unassailable thinking about breast cancer – that mammograms save lives. They’ve discovered that the benefits of the screening are modest. In a study published Wednesday in the New England Journal of Medicine, researchers report the results of a study that followed more than 40,000 Norwegian women between 50 and 69 with breast cancer. Because Norway introduced mammogram-based screening programs to its 19 counties gradually, some of the women were diagnosed before their county had regular screening, while others were diagnosed after.
The researchers found that women who were screened with a mammogram had a 28 per cent lower risk of death from breast cancer, only a third of that reduction was due to screening itself. Among women in the screening group, the breast cancer death rate declined by 7.2 deaths per 100,000 people compared with women in the decade before the screening program started. The death rate in the non-screening group fell by 4.8 deaths per 100,000 people compared with its historical counterpart.
That means that mammography reduced mortality by only 2.4 deaths per 100,000 people — a third of the total risk of death.
They expected the mortality rate to be reduced by 30 per cent after 10 years. So after 10 years we wanted to see if that was the case. And finding a 10 per cent reduction, instead of 30 per cent reduction was a surprise to us,” study co- author Dr. Mette Kalager of the Harvard School of Public Health told CTV News.
Kalager’s team found that based on the data they gathered, they estimate that 2,500 women over the age of 50 would need regular mammograms over a decade, to prevent just one woman from dying of breast cancer. At the same time though, thousands of other women would have received false positives and forced to undergo further invasive testing and biopsy procedures. It’s a result that some researchers call “uncomfortable,” because it questions the value of something promoted as a “health home run,” and suggests that mammography may not be as powerful a lifesaving tool as once thought. The World Health Organization estimates that mammograms reduce the breast cancer death rate by 25 per cent in women over 50. Other groups put the figure at 15 to 23 per cent. Other studies have questioned whether looking for breast cancer in otherwise healthy older women, may turn up small cancers that may not need aggressive treatment.
Kalager believes that the breast cancer landscape has changed in the last 20 years, so that women are more aware of breast cancer and finding breast lumps and small tumours on their own. Moreover, better breast cancer treatment is the most important factor for what’s responsible for the drop in deaths.
Only 10 per cent of one-third of the reduction we see can be attributed to that screening program. The rest is heightened awareness in the public, among doctors and then improved treatment,” she said.
Dr. Welch appears to agree, writing: “It is quite plausible that screening mammography was more effective in the past than it is now,” he writes. “The increased awareness about the importance of promptly seeking care for overt breast abnormalities… and the widespread use of adjuvant therapy have probably combined to make screening now less important.”
Dr. Cornelia Baines with the University of Toronto’s Department of Public Health Sciences says while it’s good news that overall, breast cancer deaths are declining, this study is yet more evidence that “breast screening programs for women are not doing as much for women as they think they are.” She says women undergoing mammograms need to be better informed about how effective mammograms are, and about the “significant ill effects that may occur” because of a false positive.
In the U.S., a fierce debate was ignited last year when an influential panel recommended scaling back screening programs to begin at age 50 instead of 40 – putting the guidelines in line with those in Canada and Europe. The advice was rejected by the American Cancer Society and other experts, who worried the change would lead to unnecessary deaths.
Dr. Welch notes that the current advice given to women is unlikely to change overnight and that debate continues.
Mammograms remain a critical tool for finding out if a breast lump is actually cancer. But its role to find small growths is increasingly coming under scientific scrutiny,” he said. “There’s no right answer. It’s something all women have to recognize this is a close call and different women can make different decisions.”

Further links

UK Breast Screening Guidelines

What is mammography?


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