Tag Archives: antioxidant

Support grows for antioxidant protection in heart disease

There is a lot of talk about “oxidative stress” and heart disease. This process results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium (the lining found within blood vessels) and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is regulated by ROS that degrade NO, uncouple NO synthase, and inhibit its production. Cardiovascular risk conditions contribute to oxidative stress, causing an imbalance between NO and ROS, with a relative decrease in NO bioavailability. Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability.
Diet and nutrition play a fundamental role in cardiovascular prevention and in maintaining physiological homeostasis. Recent literature emphasizes the potential therapeutic effects of micronutrients found in natural products, indicating positive applications for controlling the pathogenesis of chronic cardiovascular disease. In this context, cocoa, some chocolates, red wine, and tea received much attention, because they are particularly rich in flavonoids, phytochemicals with strong antioxidant properties. In addition, polyphenols are the most abundant antioxidants in our diet and are common constituents of foods of plant origin and are widespread constituents of fruits, vegetables, cereals, olive, dry legumes, chocolate and beverages, such as tea, coffee and wine.
The full study is available for down load (click here) where the reaserchers conclude that these key antioxidants exert a protective and preventative finctio in the battle against atherosclerosis and cardiovascular disease.
Related links
Product links

Leave a comment

Filed under Clinic News, Health News, Just for interest, Product News

Antioxidant supplements & artery health – the latest!

Just published… a key study looking at the effect of antioxidant supplementation with vitamin C, vitamin E, coenzyme Q10 and selenium on arterial health and  inflammation. As the research gathers pace, heart disease and the clogging of the arteries known as atherosclerosis is being view more as an inflammatory disease rather than a passive accumulation of fatty material within the walls of blood vessels.

This latest paper helps support the long held theory that antioxidants can help off set this process and protect the health of the cardiovascular system.

In this study, 70 people with two diagnosed cardiovascular risk factors (see the study for details) were recruited from a hypertension clinic. 35 people were given a 6 month course of capsules containing vitamin C (500 mg) vitamin E (200 iu), co- enzyme Q10 (60 mg) and selenium (100 mcg) while the other 35 were given a placebo. The summary conclusion is displayed below and the results and technicalities can be viewed by following the link at the end of this post.

Conclusions: Antioxidant supplementation significantly increased large and small artery elasticity in patients with multiple cardiovascular risk factors. This beneficial vascular effect was associated with an improvement in glucose and lipid metabolism as well as decrease in blood pressure.

The original paper is free to download from the open access journal by clicking here.

Shargorodsky M, Debbi O, Matas, Z, Zimlichman R. Effect of long term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutrition & Metabolism 2010, 7:55 doi: 10.1186/1743-7075-7-55

Product links

Leave a comment

Filed under Clinic News, Health News

Limited offer on Smart Q10

If you are a co-enzyme Q10 user – read on… We have a special but limited supply of Smart Q10 that is being offered on a but-1-get-1-FREE deal. This is a genuinely unique product and to our knowledge, the only Q10 product that can boast that 21 studies in support of its use.See April 28th blog entry for a list of these studies.

Q10, also referred to as coenzyme Q 10 or ubiquinone, is a natural fat-soluble nutrient present in virtually all living cells in the body. CoQ10 has a crucial role as a cofactor in the mitochondrial synthesis of cellular energy. Although it is produced by the body and exists in some dietary sources, these levels may be insufficient to meet the body’s requirement.

Leave a comment

Filed under Product News

Have you heard of quercetin – if not read on…

Quercetin is a natural substance, known as a bioflavonoid, that’s found in red wine, onions, and green tea. It’s been clinically shown to have antioxidant, anti-inflammatory and antimicrobial properties. Antioxidants can neutralize free radicals and may reduce or even help prevent some of the damage they cause. They also help keep LDL (“bad”) cholesterol from being damaged, which scientists think may contribute to heart disease. growing interest in this compound has developed with the finding that it acts like an antihistamine and an anti-inflammatory. some research also indicates that it may help protect against heart disease and cancer.
At this time of year hayfever and allergic asthma starts to peek. Since quercetin prevents immune cells from releasing histamines, chemicals that cause allergic reactions, its use at this time of year may offer new hope to hay fever sufferers. Researchers think that quercetin may help reduce symptoms of allergies, including runny nose, watery eyes and may be hives.
Work on quercetin is ongoing and the research data is accululating with good indications that as a natural supplement it may help in the battle against heart disease. It has been noted that since it prevents LDL cholesterol from being damaged buy oxidation artery disease may be prevented.  One study found that people who took quercetin and an alcohol-free red wine extract (which contains quercetin) had less damage to LDL cholesterol. Recent studies have also found a positive effect in cases of prostatitis. This condition is typically difficult to manage so the use of a simple supplement may come as great relief to prostatitis sufferers!
As previopusley mentioned, this compound is found normally in the diet. Fruits and vegetables (particularly citrus fruits, apples, onions, parsley, tea, and red wine) are the best dietary sources of quercetin. Olive oil, grapes, dark cherries, and dark berries (especially the dark coloured ones eg.blueberries, blackberries, and bilberries) are also high in flavonoids, including quercetin. Eating a diet rich in these is always a good idea but those with specific health needs will probably find a supplement a good idea.
In general, for allergy problems its woirth trying 500-600mg per day increasing to 500mg twice a day in cases of severe inflammation such as prostatitis.
As far as interactions with drugs goies, its generally accecpted that blood thinners such as Warfarin (Coumadin), Clopidogrel (Plavix) and Aspirin may interact with quercetin and its not recommended that you take it if you are on these. There is some suggestion that the immune suppressant drug called Cyclosporine may pose a problem because of quercetins ability to apparently blosk its absorbtion. Other drugs that have been implicated as interaction are nifedipine, and felodipine.
Quercetin is a natural substance, known as a bioflavonoid, that’s found in red wine, onions, and green tea. It’s been clinically shown to have antioxidant, anti-inflammatory and antimicrobial properties. Antioxidants can neutralize free radicals and may reduce or even help prevent some of the damage they cause. They also help keep LDL (“bad”) cholesterol from being damaged, which scientists think may contribute to heart disease. growing interest in this compound has developed with the finding that it acts like an antihistamine and an anti-inflammatory. some research also indicates that it may help protect against heart disease and cancer.At this time of year hayfever and allergic asthma starts to peek. Since quercetin prevents immune cells from releasing histamines, chemicals that cause allergic reactions. On that basis, researchers think that quercetin may help reduce symptoms of allergies, including runny nose, watery eyes and may be hives. Work on quercetin is ongoing and the research data is accululating with good indications that as a natural supplement it may help in the battle against heart disease. It has been noted that since it prevents LDL cholesterol from being damaged buy oxidation artery disease may be prevented.  One study found that people who took quercetin and an alcohol-free red wine extract (which contains quercetin) had less damage to LDL cholesterol. Recent studies have also found a positive effect in cases of prostatitis. This condition is typically difficult to manage so the use of a simple supplement may come as great relief to prostatitis sufferers! As previopusley mentioned, this compound is found normally in the diet. Fruits and vegetables (particularly citrus fruits, apples, onions, parsley, tea, and red wine) are the best dietary sources of quercetin. Olive oil, grapes, dark cherries, and dark berries (especially the dark coloured ones eg.blueberries, blackberries, and bilberries) are also high in flavonoids, including quercetin.
Eating a diet rich in these is always a good idea but those with specific health needs will probably find a supplement a good idea.In general, for allergy problems its woirth trying 500-600mg per day increasing to 500mg twice a day in cases of severe inflammation such as prostatitis.
As far as interactions with drugs goies, its generally accecpted that blood thinners such as Warfarin (Coumadin), Clopidogrel (Plavix) and Aspirin may interact with quercetin and its not recommended that you take it if you are on these. There is some suggestion that the immune suppressant drug called Cyclosporine may pose a problem because of quercetins ability to apparently blosk its absorbtion. Other drugs that have been implicated as interaction are nifedipine, and felodipine.

Leave a comment

Filed under Product News

The smart choice is Smart-Q10!

What is it and how does it work?
CoQ10, also referred to as coenzyme Q 10 or ubiquinone, is a natural fat-soluble nutrient present in virtually all living cells in the body. CoQ10 has a crucial role as a cofactor in the mitochondrial synthesis of cellular energy. Although it is produced by the body and exists in some dietary sources, these levels may be insufficient to meet the body’s requirement. A deficiency can result from impaired synthesis due to nutritional deficiencies, increasing age, or increased tissue demands. Numerous diseases may exhibit CoQ10 depletion. CoQ10 also functions as a potent antioxidant.
However, all CoQ10 products are not equal. They vary greatly in quality and absorbability. Serum level determination of CoQ10 in the bloodstream is not necessarily the most important measure of efficacy. In order for it to be fully effective, it must cross the cellular barrier and raise the intracellular levels. The only reliable indicator of CoQ10 supplementation is its presence in cell mitochondria. In central nervous system applications, CoQ10 must pass the blood brain barrier, resulting in increased brain intracellular levels to exert its effects.
Smart Q10™ CoQ10 is currently the only coenzyme Q10 supplement supported by studies that show increased serum levels, increased intracellular levels, and demonstrated ability to cross the blood brain barrier.
Smart Q10 CoQ10 wafers contain coenzyme Q10 emulsified in vitamin E and mixed tocopherols and is formulated with Micosolle®, a proprietary excipient.1 Clinical studies have demonstrated that this process enhances the absorption of CoQ10.
Two different methods can be used for the production of coenzyme Q10. One method is natural and the other is synthetic. The natural process utilizes living organisms and is referred to as a “biological fermentation/extraction process.” Coenzyme Q10 can also be synthesized by a chemical process, which produces a similar, but distinctly different product that contains chemical compounds not found in the natural form. smart Q10 CoQ10 contains the natural form of coenzyme Q10.

The Mitochondria
Mitochondria are highly specialized structures (organelles) within each nucleated cell. The number of mitochondria in a cell depends on the cell’s function. Cells with particularly heavy energy demands, such as heart muscle cells, have more mitochondria than other cells. The mitochondria’s primary responsibility is to capture most of the energy in nutrients and convert it into cellular energy. This energy conversion and storage is a complex, multi-step process that follows a specific pathway.
The converted cellular energy is stored in the energy-yielding molecule adenosine triphosphate (ATP) used to fuel the cell’s activities. (This is similar to the energy stored in gasoline that is used to fuel automobiles). Because this process requires oxygen, it is often referred to as cellular respiration. Obtaining as many electrons out of the nutrients as possible is the goal of cellular respiration. That is why part of the pathway is referred to as the electron pathway chain. CoQ10 functions as a vital link in the process of converting nutrients into ATP. Cellular respiration and the electron transport chain are completely dependent on CoQ10.
Mitochondrial Compartments
Mitochondria are encased in double membranes. The smooth outer membrane encloses the periphery of the mitochondria and the inner membrane is enfolded to form the cristae. CoQ10 is found in the cristae folds. Cristae folds provide a large surface area for cellular respiration.
Mitochondria are unusual organelles in that they contain their own deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).9,10 Insufficient CoQ10 levels may have an effect on cellular respiration and mitochondrial DNA.
Smart Q10™ CoQ10 and Support of Cardiac Health
Cardiac cells require large amounts of uninterrupted energy. They have a greater number of mitochondria and subsequently more CoQ10 than any other type of cell. Because of this association, CoQ10’s support of cardiac health is well researched and documented. CoQ10 supports healthy heart contractility and subsequent circulation, blood pressure, and exercise endurance. Due to Smart Q10 CoQ10’s ability to pass through the cell membrane and enter the mitochondria, enhanced levels can be attained.
Smart Q10™ CoQ10 and Support of the Neurological System
The Blood-Brain Barrier
The blood-barrier is a unique anatomical structure. Simply stated, the cells that make up the blood vessels that provide blood to the brain are extremely close together. This greatly restricts what can and cannot leave the bloodstream and enter the brain. While the blood-brain barrier protects the brain from potentially toxic substances, it can be a significant obstacle to therapy of central nervous system disorders. In order to leave the bloodstream and reach the brain cells, a substance must be able to pass through the tightly connected cells of the capillary walls. Only substances with certain solubilities or those that have a transport system can cross the blood-brain barrier to a significant degree.
Recently, CoQ10 has been studied for its effect in support of neurological health. When CoQ10 crosses the blood-brain barrier, mitochondrial concentrations are increased and clinical results indicate that significant neurosupportive effects follow. Clinical studies have examined the role of CoQ10 in the neurological system.
Smart Q10™ CoQ10 and Support of Immune Health
CoQ10 is necessary for immune health.† Increased free radical activity causes damage to cell membranes, mitochondria, and DNA. Supplementation with CoQ10 provides enhanced antioxidant activity that is supportive of the immune system.
Natural Vitamin E
The common name “vitamin E” is an umbrella term for a family of compounds known as the tocopherols. There are at least 8 forms of tocopherols including, alpha-tocopherol, beta-tocopherol, delta-tocopherol, and gamma-tocopherol. These tocopherols are all naturally created by plants, and when used in vitamin E supplements, are considered natural vitamin E.
Recently, the concomitant administration of vitamin E and CoQ10 has been studied. Research has demonstrated that CoQ10 can improve vitamin E’s antioxidant function and protect it from depletion.
Smart Q10™  and Clinical Trials
The formulation of Smart Q10™ CoQ10 is unique among CoQ10 supplements. Currently, three large multi-center studies investigating Smart Q10™ CoQ10 are ongoing. All of these clinical trials are investigating Smart Q10™ CoQ10 health supportive effects on the nervous system. To date, 21 published studies have used Smart Q10™ CoQ10 in their research.
The 21 Studies and Presentations at Medical Symposiums Utilizing Vitaline® Coenzyme Q10 Dietary Supplement Products:
  1. Matthews RT, Yang L, Browne S, Baik MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA. 1998; 95:8892-8897.
  2. Langsjoen P. Overview of the use of CoQ10 in cardiovascular disease. Presented at The First Conference of the International Coenzyme Q10 Association. Boston, Mass, May 21-24, 1998.
  3. Koroshetz W. Huntington’s Disease Clinical Trail. Presented at the First Conference of the International Coenzyme Q10 Association. Boston. Mass, May 21-24, 1998.
  4. Shults CW, Haas RH, Flint Beal M. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson’s disease. Proceedings of First Conference of the International Coenzyme Q10 Association, 95:8892-8897, July 21, 1998.
  5. Beal MF. Coenzyme Q10 as a potential treatment for neurodegenerative diseases. Presented at the First Conference of the International Coenzyme Q10 Association. Boston. Mass, May 21-24, 1998.
  6. Beal MF. Energy impairment and Huntington’s disease. Presented at the Mitochondrial Medicine Conference. University of California, San Diego School of Medicine, Mitochondrial and Metabolic Disease Center, San Diego, Calif, Feb 19-21, 1998.
  7. Kieburtz K, Rickey T. Co-enzyme Q10 and remacemide: evaluation in Huntington¡¦s disease (CARE-HD). A controlled investigation by the Huntington Study Group. Clinical trial in progress. Institutions participating in the CARE-HD Study: Allegheny University, Baylor College of Medicine, Boston University, Bowman Gray School of Medicine, Colorado Neurological Institute, Columbia-Presbyterian, Emory University, Indiana School of Medicine, Johns Hopkins University, Massachusetts General Hospital, Rush-Presbyterian-St.Luke’s Medical Center, Tampa General Hospital, and the universities of Alberta, British Columbia, Calgary, Iowa, Kansas Medical Center, Miami School of Medicine, Michigan, Rochester, Toronto, and Virginia. June 1997-2002.
  8. Langsjoen PH, Langsjoen A, Willis R, Folkers K. Treatment of hypertrophic cardiomyopathy with coenzyme Q10. Mol Aspects Med. 1997;18:S145-S151.
  9. Shults CW, Flint Beal MD, Fontaine D, Nakeno K, Haas RH. Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology. 1998;50:793-795.
  10. Flint Beal M, Matthews RT, Tielman A, Shults CW. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetradopyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 1998;783:109-114.
  11. Flint Beal M, Matthews RT. Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative disease. Mol Aspects Med. 1997;18:S169-S179.
  12. Schwid SR, Mattson DH, Goodman AD. A phase II trial of coenzyme Q10 in MS. Clinical trial in progress. University of Rochester, Department of Neurology, Neuroimmunology Unit, Rochester, New York. 1996-2000.
  13. Koroshetz W. Huntington’s Disease Clinical Trail. Presented at the First Conference of the International Coenzyme Q10 Association. Boston, Mass, May 21-24, 1998.
  14. Shults CW, Haas RH, Passov D, Flint Beal M Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997;42:261-264.
  15. Feigin A, Kieburtz K, Como C, et al. Assessment of coenzyme Q10 tolerability in Huntington’s disease. Mov Disord. 1996;11:321-323.
  16. Cros D. Amyotrophic Lateral Sclerosis (ALS). Harvard Medical School- Massachusetts General Hospital Department of Neurology EMG Unit-Bigelow 12, Boston, Mass, 1995-1998.
  17. Tardive Dyskinesia Study Using Coenzyme Q10 and Nicotinamide. Harvard Medical School-Massachusetts General Hospital Department of Psychiatry and Neurology, Freedom Trial Clinic, Erich Lindemann Mental Health Center, Boston, Mass, 1995.
  18. Costeff H. CoQ10 and 3-Methylglutaconic Aciduria. Neuropediatric Unit. Loewenstein Hospital Rehabilitation Center, Tel Aviv. Medical School, Raanana, Israel, 1998.
  19. Flint Beal. Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience. 1996;71:1043-1048.
  20. Flint Beal M, Henshaw R, Jenkins BG, Rosen BR, Schulz JB. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Ann Neurol 1994;36:882-888.
  21. Schulz JB, Henshaw RD, Matthews RT, Flint Beal M. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Exp Neurol. 1995;132:279-283.

Leave a comment

Filed under Product News